Research Scientist – Pharmacology/Biochemistry

LQT Therapeutics - Laval, QC (il y a 30+ jours)

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LQT Therapeutics is a startup developing drug to treat the Long QT Syndrome.

Responsibilities

  • Conceive, communicate and execute innovative multi-disciplinary research strategies that encompass target validation, small molecule drug discovery and clinical candidate selection.
  • Hands-on cell-based assays to screen our drug candidates for efficacy, MOA and safety
  • Familiarity with determination of drug potencies using concentration-effects curves and non-linear regression
  • Develop and troubleshoot in vitro methods for assessment of drug efficacy at target(s) of interest
  • Manage outsourced research to evaluate pharmacologic, ADME, safety and toxicologic properties of candidate drug molecules, including identification and selection of preferred external research partners.
  • Preclinical samples management (inventory of received samples & storage)
  • Organization, documentation and reporting of methods and results
  • Thorough record keeping through database and notebook entries
  • Familiarity with the nonclinical requirements of efficacy, safety and toxicity assessment of drugs under an US IND
  • Positive and collaborative disposition with the ability to work easily within a team

Qualifications

  • Ph.D. degree in biochemistry, pharmacology or related field
  • More than 3 years of relevant industry experience (level to be commensurate with education and experience)
  • Experience with establishing and conducting in vitro electrophysiology studies to determine drug effects under voltage/current clamp
  • Experience establishing and conducting in vitro enzymatic assays to determine drug effects
  • Creativity, a high degree of independence, and enthusiasm to learn new skills
  • Ability to communicate effectively, both verbally and written
  • Able to work independently, as well as a part of an interdisciplinary team
  • Ability to manage multiple competing priorities, while working on multiple projects simultaneously
  • Proficiency with spreadsheet, word processing, and graphical computer programs (MS EXCEL, MS WORD, non-linear regression software e.g. GraphPad Prism) required

Experience:

  • Industry: more than 3 years
  • Laboratory: more than 3 years

Education:

Ph.D in biochemistry or pharmacology

Job Type: Full-time

Experience:

  • laboratory: 3 years (Required)
  • industrial: 3 years (Required)

Education:

  • Doctoral Degree (Required)

Language:

  • English (Required)